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Recombinant Human CD16b/FCGR3B Protein, Biotinylated

Uniprot : O75015

Cat.No.:PKSH030308
Expression host: E.coli

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Description

Synonyms	Low affinity immunoglobulin gamma Fc region receptor III-B;Fc-gamma RIII-beta;FcR-10;IgG Fc receptor III-1;FCG3;FCGR3;CD16b and FCGR6B;FCRIII;FCRIIIb
Species	Human
Expression_host	E.coli
Sequence	Met 18-Gly 193
Accession	O75015-1
Application	Functional ELISA
Mol_Mass	20.0 kDa
Tag	None
Bio_Activity	1. Measured by its ability to bind human IgG1 in a functional ELISA. 2. Labeling ratio of biotin to protein: 5. 51.

Properties

Purity	> 90 % as determined by reducing SDS-PAGE.
Endotoxin level	Please contact us for more information.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Low affinity immunoglobulin gamma Fc region receptor III-B; also known as Fc-gamma RIII-beta; FcR-10; IgG Fc receptor III-1; FCG3; FCGR3; CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of inflammation and their activation. FCGR3B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

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