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Recombinant Human EGFR/ErbB1 Protein (aa 668-1210, His&GST Tag)

Uniprot : P00533

Cat.No.:PKSH030428
Expression host: Baculovirus-Insect Cells

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50μg

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Description

Synonyms	ERBB;ERBB1;HER1;mENA;NISBD2;PIG61
Species	Human
Expression_host	Baculovirus-Insect Cells
Sequence	Met 668-Ala 1210
Accession	NP_005219
Mol_Mass	89.1 kDa
Tag	N-His-GST
Bio_Activity	The specific activity was determined to be 105 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.

Properties

Purity	> 85 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
Reconstitution	Not Applicable

Background

As a member of the epidermal growth factor receptor (EGFR) family; EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF; amphiregulin; TGF-α; betacellulin; etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation; survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization; the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK; PI3K/PKB and STAT). In addition; EGFR signaling also has been shown to exert action on carcinogenesis and disease progression; and thus EGFR protein is proposed as a target for cancer therapy currently.

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