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The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. However, little is known about its exact function. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia, whereas the L-selectin to which it binds is on the T cell. Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumens. Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration.
|Full Name||Recombinant Human Hematopoietic progenitor cell antigen CD34 protein|
|Species||Homo sapiens (Human)|
|Purity||>90% as determined by SDS-PAGE|
|Expression Host||E. coli|
|Protein Description||Recombinant Human Hematopoietic progenitor cell antigen CD34 domain(Ser 32-Thr 290) with a N-terminal polyhistidine tag|
|Predicted N Terminal||Ser 32|
|Expression Region||32-290 aa|
|Formulation||Tris-based buffer, 50% glycerol|
|Stability||Samples are stable for up to 12 months from date of receipt at -70℃ .|
|Storage||Store at -20 ℃ (regular) and -80℃ (long term). Avoid freeze or thaw cycles|
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