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CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation.
|Full Name||Recombinant human Carcinoembryonic antigen-related cell adhesion molecule 5 protein|
|Synonym||Carcinoembryonic antigen,Meconium antigen 100,CD_antigen: CD66e|
|Species||Homo sapiens (Human)|
|Purity||>90% as determined by SDS-PAGE|
|Expression Host||E. coli|
|Protein Description||Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 domain(Lys 35-Ala 685) with a N-terminal polyhistidine tag|
|Predicted N Terminal||Lys 35|
|Expression Region||35-685 aa|
|Formulation||Tris-based buffer,50% glycerol|
|Stability||Samples are stable for up to 12 months from date of receipt at -70℃ .|
|Storage||Store at -20 ℃ (regular) and -80℃ (long term). Avoid freeze or thaw cycles|
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