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Recombinant Human CEACAM5 protein

CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation.

Product Introduction


 Full  Name  Recombinant human Carcinoembryonic antigen-related cell adhesion molecule 5 protein
 Synonym  Carcinoembryonic antigen,Meconium antigen 100,CD_antigen: CD66e
 Cat.No  PHN020388
 Species  Homo sapiens (Human)
 Purity  >90% as determined by SDS-PAGE
 Expression  Host  E. coli
 Expression  Vector  PET28a
 Protein Description  Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 domain(Lys 35-Ala 685) with a N-terminal polyhistidine tag
 Predicted  N Terminal  Lys 35
 Tag  Information  His-tagged
 Expression  Region  35-685 aa
 Molecular Mass  75kD
 Formulation  Tris-based buffer,50% glycerol
 Stability  Samples are stable for up to 12 months from date of receipt at -70℃ .
 Storage  Store at -20 ℃ (regular) and -80℃ (long term). Avoid freeze or thaw cycles
 Peptide SequenceKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSA

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