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Recombinant Human CASP3 protein

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Product Introduction


 Full  Name  Recombinant human Caspase-3 protein
 Synonym  Apopain,Cysteine protease CPP32,CPP-32,Protein Yama,SREBP cleavage activity 1
 Cat.No  PHN020389
 Species  Homo sapiens (Human)
 Purity  >90% as determined by SDS-PAGE
 Expression  Host  E. coli
 Expression  Vector  PET28a
 Protein Description  Recombinant Human Caspase-3 domain(Ser 29-His 277) with a N-terminal polyhistidine tag
 Predicted  N Terminal  Ser 29
 Tag  Information  His-tagged
 Expression  Region  29-277 aa
 Molecular Mass  32kD
 Formulation  Tris-based buffer,50% glycerol
 Stability  Samples are stable for up to 12 months from date of receipt at -70℃ .
 Storage  Store at -20 ℃ (regular) and -80℃ (long term). Avoid freeze or thaw cycles
 Peptide SequenceSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

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