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Recombinant Human STAT1 protein

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.

Product Introduction


 Full  Name  Recombinant human Signal transducer and activator of transcription 1-alpha/beta protein
 Synonym  Transcription factor ISGF-3 components p91/p84
 Cat.No  PHN020414
 Species  Homo sapiens (Human)
 Purity  >90% as determined by SDS-PAGE
 Expression  Host  E. coli
 Expression  Vector  pCold-GST
 Protein Description  Recombinant Human Signal transducer and activator of transcription 1-alpha/beta domain(Ser 2-Gly 250 ) with a N-terminal His&GST tag
 Predicted  N Terminal  Ser 2
 Tag  Information  His&GST-tagged
 Expression  Region  2-250 aa
 Molecular Mass  52kD
 Formulation  1*PBS PH 7.4
 Stability  Samples are stable for up to 12 months from date of receipt at -70℃ .
 Storage  Store at -20 ℃ (regular) and -80℃ (long term). Avoid freeze or thaw cycles
 Peptide SequenceSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGG

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