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Recombinant Human MYD88 protein

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Product Introduction


 Full  Name  Recombinant human Myeloid differentiation primary response protein MyD88 protein
 Synonym  
 Cat.No  PHN020418
 Species  Homo sapiens (Human)
 Purity  >90% as determined by SDS-PAGE
 Expression  Host  E. coli
 Expression  Vector  PET28a
 Protein Description  Recombinant Human Myeloid differentiation primary response protein MyD88 domain(Met 1-Pro 296 ) with a N-terminal polyhistidine tag
 Predicted  N Terminal  Met 1
 Tag  Information  His-tagged
 Expression  Region  1-296 aa
 Molecular Mass  37kD
 Formulation  Tris-based buffer, 50% glycerol
 Stability  Samples are stable for up to 12 months from date of receipt at -70℃ .
 Storage  Store at -20 ℃ (regular) and -80℃ (long term). Avoid freeze or thaw cycles
 Peptide SequenceMAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLEIRQLETQADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQQQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP

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