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Recombinant Human CD207 protein

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.

Product Introduction


 Full  Name  Recombinant human C-type lectin domain family 4 member K protein
 Synonym  Langerin,CD_antigen: CD207
 Cat.No  PHN020421
 Species  Homo sapiens (Human)
 Purity  >90% as determined by SDS-PAGE
 Expression  Host  E. coli
 Expression  Vector  PET28a
 Protein Description  Recombinant Human C-type lectin domain family 4 member K domain(Pro 65-Pro 328 ) with a N-terminal polyhistidine tag
 Predicted  N Terminal  Pro 65
 Tag  Information  His-tagged
 Expression  Region  65-328 aa
 Molecular Mass  32kD
 Formulation  Tris-based buffer, 50% glycerol
 Stability  Samples are stable for up to 12 months from date of receipt at -70℃ .
 Storage  Store at -20 ℃ (regular) and -80℃ (long term). Avoid freeze or thaw cycles
 Peptide SequencePRFMGTISDVKTNVQLLKGRVDNISTLDSEIKKNSDGMEAAGVQIQMVNESLGYVRSQFLKLKTSVEKANAQIQILTRSWEEVSTLNAQIPELKSDLEKASALNTKIRALQGSLENMSKLLKRQNDILQVVSQGWKYFKGNFYYFSLIPKTWYSAEQFCVSRNSHLTSVTSESEQEFLYKTAGGLIYWIGLTKAGMEGDWSWVDDTPFNKVQSARFWIPGEPNNAGNNEHCGNIKAPSLQAWNDAPCDKTFLFICKRPYVPSEP

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