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ALK,CD246 Monoclonal Antibody
Cat.No:EPM12136
Price: Inquire
Immunogen: ALK,CD246 fusion protein ag21493
Synonym:
ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK
Calculated MW: 1620aa,176 kDa
Observed MW: Refer to figures
Source:
Mouse
Isotype:
IgG2a
Reactivity: H;

Clonality: Monoclonal


Application:
ELISA,IHC,WB
Purify:
Protein A purification
Concentration:
Storage Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
ALK,CD246 Monoclonal Antibody
Recombinant protein were subjected to SDS PAGE followed by western blot with ALK,CD246 antibody at dilution of 1:1000
Protocols:
Background:
ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).
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