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Alpha-1-Antitrypsin Monoclonal Antibody
Cat.No:EPM12140
Price: Inquire
Immunogen: Alpha-1-Antitrypsin fusion protein ag9516
Synonym:
A1A, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 protease inhibitor, PI, PI1, PRO2209, PRO2275, Serpin A1, SERPINA1, SPAAT, α1-antitrypsin
Calculated MW: 418aa,47 kDa
Observed MW: 51 kDa
Source:
Mouse
Isotype:
IgG1
Reactivity: H;

Clonality: Monoclonal


Application:
ELISA,WB,IHC,IF
Purify:
Protein G purification
Concentration:
Storage Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
Alpha-1-Antitrypsin Monoclonal Antibody
HepG2 cells were subjected to SDS PAGE followed by western blot with Alpha-1-Antitrypsin antibody at dilution of 1:10000
Protocols:
Background:
SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.
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