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RSPO3 Monoclonal Antibody
Cat.No:EPM12469
Price: Inquire
Immunogen: RSPO3 fusion protein ag9899
Synonym:
CRISTIN1, FLJ14440, hPWTSR, hRspo3, Protein with TSP type 1 repeat, PWTSR, R spondin 3, Roof plate specific spondin 3, RSPO3, THSD2
Calculated MW: 272aa,31 kDa
Observed MW: 32 kDa
Source:
Mouse
Isotype:
IgG2b
Reactivity: H;

Clonality: Monoclonal


Application:
ELISA,WB
Purify:
Protein A purification
Concentration:
Storage Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
RSPO3 Monoclonal Antibody
human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with RSPO3 antibody at dilution of 1:2000
Protocols:
Background:
RSPO3, also named as R-spondin-3, is a 272 amino acid protein, which contains 1 TSP type-1 domain and 2 FU (furin-like) repeats. RSPO3 may be a secreted protein and belongs to the R-spondin family. RSPO3 is expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. The four R-spondins (RSPO1–4) and three related leucinerich repeat-containing G-protein coupled receptors, LGR4, LGR5, and LGR6 (LGR4–6), constitute a ligand–receptor system that plays critical roles in development, stem cell survival, and oncogenesis. Ectopic expression of RSPO2/3in mouse mammary epithelial cells led to an increase in invasiveness in vitro and in tumor formation and metastasis in vivo.
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