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RXRA Monoclonal Antibody
Cat.No:EPM12470
Price: Inquire
Immunogen: RXRA fusion protein ag0987
Synonym:
FLJ00280, FLJ00318, FLJ16020, FLJ16733, NR2B1, Retinoid X receptor alpha, retinoid X receptor, alpha, RXRA
Calculated MW: 17.8 kDa
Observed MW: 44kd
Source:
Mouse
Isotype:
IgG1
Reactivity: H,M;

Clonality: Monoclonal


Application:
ELISA,WB
Purify:
Protein G purification
Concentration:
Storage Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
RXRA Monoclonal Antibody
HeLa cells were subjected to SDS PAGE followed by western blot with RXRA antibody at dilution of 1:100
Protocols:
Background:
Retinoid X receptor alpha (RXRA). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and ranscriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. This antibody is a rabbit polyclonal antibody raised against the 350 AA of human RXRA C-terminal. RXRA is highly expressed in liver, also expressed in lung, kidney and heart.
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