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Human IL-1β(Interleukin 1 Beta) ELISA Kit

  • Cat.No.:E-EL-H0149

  • Reactivity: Human

To Purchase E-EL-H0149

Size:
  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $495
Qty:

Product Details

Properties

Assay type Sandwich-ELISA
Format 96T/48T/24
Assay time 3.5h
Detection range 7.81-500 pg/mL
Sensitivity 4.69 pg/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Human IL-1β in samples. No significant cross-reactivity or interference between Human IL-1β and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Human IL-1β concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IL-1β. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Human IL-1β and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IL-1β, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Human IL-1β. You can calculate the concentration of Human IL-1β in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
ItemSpecificationsStorage
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips
-20℃, 12 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
-20℃(Protect from light), 12 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 12 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Human IL-1β were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Human IL-1β were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 27.70 46.20 197.60 29.10 47.80 192.60
Standard deviation 1.40 2.60 9.50 1.70 2.80 6.00
CV (%) 5.05 5.63 4.81 5.84 5.86 3.12

Recovery

The recovery of Human IL-1β spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 94-110 100
EDTA plasma (n=8) 89-102 95
Cell culture media (n=8) 84-98 91

Linearity

Samples were spiked with high concentrations of Human IL-1β and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt:   P01584
SynonymsIL1B, IL1-BETA, IL1F2, catabolin
Research AreaCancer, Cardiovascular, Metabolism, Immunology

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C

elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C

elisa assay procedure 3

3. Aspirate and wash the plate for 3 times

elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times

elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C

elisa assay procedure 6

6. Add 50μL Stop Solution

elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results

Citations

  1. Aging-US (2020) IF: 4.831
    K63 ubiquitin chains target NLRP3 inflammasome for autophagic degradation in ox-LDL-stimulated THP-1 macrophages

    DOI: 10.18632/aging.102710

    PMID: 32003754

    Sample: Cell Culture Supernatant
  2. Aging-US (2020) IF: 4.831
    Electrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation

    DOI: 10.18632/aging.103038

    Sample: Thp-1 Cell
  3. Frontiers in Nutrition (2022) IF: 6.59
    Different oral and gut microbial profiles in those with Alzheimer's disease consuming anti-inflammatory diets.

    DOI: 10.3389/fnut.2022.974694

    Sample: Serum
  4. Cell Death Discovery (2017) IF: 5.241
    The principles and attentions of Immunohistochemistry

    DOI: 10.1038/cddiscovery.2016.107

    Sample: Nucleus Pulposus (Np) Cell
  5. Frontiers in Pharmacology (2022) IF: 5.988
    MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation

    DOI: 10.3389/fphar.2022.978587

    PMID: 36091773

    Sample: U87 Cell
  6. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208
    Nanoparticle Emulsions Enhance the Inhibition of NLRP3

    DOI: 10.3390/ijms231710168

    PMID: 36077562

    Sample: Thp-1 Cell
  7. PHYTOTHERAPY RESEARCH (2021) IF: 5.882
    Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial

    DOI: 10.1002/ptr.7113

    PMID: 33899292

    Sample: Serum
  8. DIABETOLOGIA (2018) IF: 6.023
    receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes

    DOI: 10.1007/s00125-018-4755-3

    Sample: Cell Culture Supernatant
  9. Frontiers in Bioengineering and Biotechnology (2022) IF: 6.064
    Scutellarin Protects Against Mitochondrial Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation to Attenuate Intervertebral Disc Degeneration.

    DOI: 10.3389/fbioe.2022.883118

    Sample: Human Primary Nucleus Pulposus Cell (Hnpc)
  10. Frontiers in Cellular Neuroscience (2022) IF: 6.147
    The SARS-CoV-2 envelope protein disrupts barrier function in an in vitro human blood-brain barrier model.

    DOI: 10.3389/fncel.2022.897564

    Sample: Hcmec/D3 Cell,U87Mg Cell
  11. Cancers (2019) IF: 6.162
    GSTO1*CC Genotype (rs4925) Predicts Shorter Survival in Clear Cell Renal Cell Carcinoma Male Patients

    DOI: 10.3390/cancers11122038

    PMID: 31861116

    Sample: Serum,Plasma,Whole Blood,Platelet
  12. Frontiers in Pharmacology (2022) IF: 5.988
    Chalcone Derivatives From Abelmoschus manihot Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization

    DOI: 10.3389/fphar.2022.932198

    PMID: 35873581

    Sample: Thp-1 Cell
  13. Marine Drugs (2023) IF: 6.085
    Mechanisms of Antitumor Invasion and Metastasis of the Marine Fungal Derivative Epi-Aszonalenin A in HT1080 Cells

    DOI: 10.3390/md21030156

    Sample: Ht1080 Cell
  14. EBioMedicine (2018) IF: 6.183
    The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway

    DOI: 10.1016/j.ebiom.2018.11.015

    PMID: 30448228

    Sample: Cell Culture Supernatant
  15. Frontiers in Pharmacology (2022) IF: 5.988
    Aconiti lateralis radix praeparata total alkaloids exert anti-RA effects by regulating NF-κB and JAK/STAT signaling pathways and promoting apoptosis.

    DOI: 10.3389/fphar.2022.980229

    Sample: Mh7A Cell
  16. JOURNAL OF MEDICAL INVESTIGATION (2022)
    Comparing the ICSI outcome between different causes of subfertility and estimate the role of IL-1β in predicting ICSI outcome.

    DOI: 10.2152/jmi.69.180

    Sample: Follicular Fluid,Serum
  17. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2022) IF: 0.533
    Dysfunctional oxidative stress response in first-episode of schizophrenia

    DOI: 10.4314/tjpr.v20i6.22

    Sample: Serum
  18. Genetic Testing and Molecular Biomarkers (2019) IF: 1.121
    Association of PAR-2 Gene Polymorphisms with the Inflammatory Response and Susceptibility to Knee Osteoarthritis in the Chinese Han Population

    DOI: 10.1089/gtmb.2018.0219

    PMID: 30688539

    Sample: Synovia
  19. Experimental and Therapeutic Medicine (2017) IF: 1.261
    Inhibition of miR‑27a suppresses the inflammatory response via the p38/MAPK pathway in intervertebral disc cells

    DOI: 10.3892/etm.2017.5053

    Sample: Cell Culture Supernatant
  20. EPILEPTIC DISORDERS (2020) IF: 1.276
    HMGB‐1, TLR4, IL‐1R1, TNF‐α, and IL‐1β: novel epilepsy markers?

    DOI: 10.1684/epd.2020.1155

    Sample: Serum
  21. International Journal of Clinical and Experimental Pathology (2018) IF: 1.396
    MicroRNA-124 alleviates hyperoxia-induced inflammatory response in pulmonary epithelial cell by inhibiting TLR4/NF-κB/CCL2

    PMID: 31938089

    Sample: Beas2B Cells
  22. Experimental and Therapeutic Medicine (2018) IF: 1.41
    Role of miR‑589‑3p in human lumbar disc degeneration and its potential mechanism

    DOI: 10.3892/etm.2017.5593

    Sample: Cell Culture Supernatant
  23. Experimental and Therapeutic Medicine (2018) IF: 1.41
    N‑methyl pyrrolidone promotes ankle fracture healing by inhibiting inflammation via suppression of the mitogen‑activated protein kinase signaling pathway

    DOI: 10.3892/etm.2018.5842

    Sample: Peripheral Blood
  24. Experimental and Therapeutic Medicine (2018) IF: 1.41
    Anti‑inflammatory effect of Resolvin D1 on LPS‑treated MG‑63 cells Corrigendum in /10.3892/etm.2019.8021

    DOI: 10.3892/etm.2018.6721

    Sample: Serum
  25. JOURNAL OF CLINICAL NEUROSCIENCE (2019) IF: 1.593
    Sex difference in IL-6 modulation of cognition among Chinese individuals with major depressive disorder

    DOI: 10.1016/j.jocn.2019.10.002

    PMID: 31629608

    Sample: Serum
  26. ARCHIVES OF ORAL BIOLOGY (2019) IF: 1.663
    Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts

    DOI: 10.1016/j.archoralbio.2019.104514

    PMID: 31394382

    Sample: Cell Culture Supernatant
  27. Molecular Medicine Reports (2017) IF: 1.692
    Tetrahydroxy stilbene glucoside ameliorates H2O2-induced human brain microvascular endothelial cell dysfunction in vitro by inhibiting oxidative stress and inflammatory responses

    DOI: 10.3892/mmr.2017.7225

    Sample: Cell Culture Supernatant
  28. International Journal of Ophthalmology (2021) IF: 1.779
    Effects of quercetin on diabetic retinopathy and its association with NLRP3 inflammasome and autophagy

    DOI: 10.18240/ijo.2021.01.06

    PMID: 33469482

    Sample: Cell Culture Supernatant
  29. MEDICAL SCIENCE MONITOR (2018) IF: 1.894
    Sinomenine Regulates Inflammatory Response and Oxidative Stress via Nuclear Factor kappa B (NF-κB) and NF-E2-Related Factor 2 (Nrf2) Signaling Pathways in Ankle Fractures in Children

    DOI: 10.12659/MSM.910740

    Sample: Serum
  30. MEDICAL SCIENCE MONITOR (2018) IF: 1.894
    Propofol Promotes Ankle Fracture Healing in Children by Inhibiting Inflammatory Response

    DOI: 10.12659/MSM.908592

    Sample: Serum
  31. Brazilian Journal of Psychiatry (2020) IF: 1.904
    Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments

    DOI: 10.1590/1516-4446-2020-0908

    PMID: 32556004

    Sample: Serum
  32. MEDICAL SCIENCE MONITOR (2020) IF: 1.918
    Avicularin Reduces the Expression of Mediators of Inflammation and Oxidative Stress in Bradykinin-Treated MG-63 Human Osteoblastic Osteosarcoma Cells

    DOI: 10.12659/MSM.921957

    PMID: 32463805

    Sample: Cell Culture Supernatant
  33. ARCHIVES OF ORAL BIOLOGY (2020) IF: 1.931
    Nec-1 attenuates inflammation and cytotoxicity induced by high glucose on THP-1 derived macrophages through RIP1

    DOI: 10.1016/j.archoralbio.2020.104858

    PMID: 32805637

    Sample: Cell Culture Supernatant
  34. Biology Open (2019) IF: 1.962
    Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway

    DOI: 10.1242/bio.043653

    Sample: L02 Cells
  35. Evidence-based Complementary and Alternative Medicine (2019) IF: 1.984
    In Vitro Immunomodulatory Effect of Food Supplement from Aloe vera

    DOI: 10.1155/2019/5961742

    PMID: 30941196

    Sample: Cell Culture Supernatant
  36. HUMAN & EXPERIMENTAL TOXICOLOGY (2020) IF: 2.067
    Investigation of DNA damage, oxidative stress, and inflammation in synthetic cannabinoid users:

    DOI: 10.1177/0960327120930057

    Sample: Plasma
  37. Molecular Medicine Reports (2020) IF: 2.1
    Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute respiratory distress syndrome in cells via regulating autophagy‑related pathway

    DOI: 10.3892/mmr.2020.11739

    PMID: 33300058

    Sample: Cell Culture Supernatant
  38. Trials (2021) IF: 2.279
    Effect of Lycium barbarum polysaccharide supplementation in non-alcoholic fatty liver disease patients: study protocol for a randomized controlled trial

    DOI: 10.1186/s13063-021-05529-6

    PMID: 34521466

    Sample: Blood
  39. MOLECULAR BIOLOGY REPORTS (2022) IF: 2.316
    NF-κB/ABCA1 pathway aggravates ox-LDL-induced cell pyroptosis by activation of NLRP3 inflammasomes in THP-1-derived macrophages

    DOI: 10.1007/s11033-022-07408-y

    PMID: 35579737

    Sample: Thp-1 Monocytes
  40. JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021) IF: 2.352
    Exploring potential serum levels of Homocysteine, interleukin-1 beta, and apolipoprotein B 48 as new biomarkers for patients with ischemic stroke

    DOI: 10.1002/jcla.23996

    PMID: 34492129

    Sample: Serum
  41. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2020) IF: 2.352
    A case of asthma with Behcet’s disease: successful treatment with omalizumab and its effects on recurrent aphthous lesions

    DOI: 10.1080/08923973.2020.1789656

    Sample: Serum
  42. CHEMISTRY & BIODIVERSITY (2021) IF: 2.408
    Total Flavonoids of Engelhardia roxburghiana Wall. Leaves Alleviated Foam Cells Formation through AKT/mTOR-Mediated Autophagy in the Progression of Atherosclerosis

    DOI: 10.1002/cbdv.202100308

    PMID: 34259387

    Sample: Thp-1 Cell
  43. BIOLOGICAL TRACE ELEMENT RESEARCH (2019) IF: 2.431
    Study of Metal-Metal Interactions and Their Biomarkers Using an Intestinal Human Cell Line

    DOI: 10.1007/s12011-019-01831-2

    PMID: 31473895

    Sample: Cell Lysate
  44. Experimental and Therapeutic Medicine (2021) IF: 2.447
    MicroRNA‑16 regulates lipopolysaccharide‑induced inflammatory factor expression by targeting TLR4 in normal human bronchial epithelial cells

    DOI: 10.3892/etm.2021.10414

    Sample: Nhbe Cells
  45. Experimental and Therapeutic Medicine (2021) IF: 2.447
    Mangiferin inhibits hypoxia/reoxygenation‑induced alveolar epithelial cell injury via the SIRT1/AMPK signaling pathway

    DOI: 10.3892/etm.2021.10654

    Sample: A549 Cell
  46. International Journal of Rheumatic Diseases (2021) IF: 2.454
    MiR-223-3p and miR-22-3p inhibit monosodium urate-induced gouty inflammation by targeting NLRP3

    DOI: 10.1111/1756-185X.14089

    PMID: 33650318

    Sample: Cell Culture Supernatant(Thp-1)
  47. DIGESTIVE DISEASES (2020) IF: 2.493
    LncRNA PMS2L2 downregulates miR-24 through methylation to suppress cell apoptosis in ulcerative colitis

    DOI: 10.1159/000513330

    Sample: Hcnepcs
  48. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018) IF: 2.559
    Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acute liver failure by reducing the activity of the NLRP3 inflammasome in macrophages

    DOI: 10.1016/j.bbrc.2018.11.189

    PMID: 30528233

    Sample: Serum
  49. Neuropsychiatric Disease and Treatment (2021) IF: 2.57
    The Combination of Insulin Resistance and Serum Interleukin-1β Correlates with Post-Stroke Depression in Patients with Acute Ischemic Stroke

    DOI: 10.2147/NDT.S291164

    PMID: 33727817

    Sample: Serum
  50. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2020) IF: 2.575
    XIST silencing alleviated inflammation and mesangial cells proliferation in diabetic nephropathy by sponging miR-485

    DOI: 10.1080/13813455.2020.1789880

    PMID: 32669002

    Sample: Serum
  51. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2022) IF: 2.586
    Upregulated NORAD is implicated in apoptosis, inflammation, and oxidative stress in ulcerative colitis through the nuclear factor-κappaB signaling

    DOI: 10.1097/MEG.0000000000002370

    PMID: 35412486

    Sample: Human Normal Colonic Mucosal Cells (Fhcs)
  52. Evidence-based Complementary and Alternative Medicine (2021) IF: 2.63
    The Anti-Inflammatory Effect of Smilax china L. Extract on LPS-Stimulated THP-1 via Downregulation of MAPK and NF-κB Signaling Pathway

    DOI: 10.1155/2021/9958808

    Sample: Thp-1 Cells
  53. Evidence-based Complementary and Alternative Medicine (2022) IF: 2.63
    Antiplatelet Activity of Tetramethylpyrazine via Regulation of the P2Y12 Receptor Downstream Signaling Pathway

    DOI: 10.1155/2022/7941039

    PMID: 35378909

    Sample: Platelets Suspensions
  54. GENE (2019) IF: 2.638
    Downregulation of hsa_circ_0068087 ameliorates TLR4/NF-κB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in high glucose conditioned by sponging miR-197

    DOI: 10.1016/j.gene.2019.05.012

    Sample: Human Umbilical Vein Endothelial Cells (Huvecs)
  55. Journal of Healthcare Engineering (2022) IF: 2.682
    Inhibition of microRNA-665 Alleviates Septic Acute Kidney Injury by Targeting Bcl-2

    DOI: 10.1155/2022/2961187

    PMID: 35281537

    Sample: Hk-2 Cell
  56. Food & Function (2016) IF: 2.686
    Antidiabetic (type 2) effects of Lactobacillus G15 and Q14 in rats through regulation of intestinal permeability and microbiota

    DOI: 10.1039/C6FO00831C

    Sample: Plasma,Serum
  57. Journal of Applied Oral Science (2022) IF: 2.698
    Granulocyte-macrophage colony-stimulating factor (GM-CSF) in subjects with different stages of periodontitis according to the new classification

    DOI: 10.1590/1678-7757-2021-0423

    PMID: 35262594

    Sample: Gingival Crevicular Fluid (Gcf)
  58. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019) IF: 2.705
    Long non-coding RNA MEG3 regulates CSE-induced apoptosis and inflammation via regulating miR-218 in 16HBE cells

    DOI: 10.1016/j.bbrc.2019.10.135

    PMID: 31668807

    Sample: Cell Culture Supernatant
  59. BMC Oral Health (2021) IF: 2.757
    The effect of conventional versus electronic cigarette use on treatment outcomes of peri-implant disease

    DOI: 10.1186/s12903-021-01784-w

    Sample: Saliva
  60. BIOMEDICINE & PHARMACOTHERAPY (2017) IF: 2.759
    Oleanolic acid protects against pathogenesis of atherosclerosis, possibly via FXR-mediated angiotensin (Ang)-(1–7) upregulation

    DOI: 10.1016/j.biopha.2017.11.151

    Sample: Cell Culture Supernatant,Serum
  61. EUROPEAN JOURNAL OF DERMATOLOGY (2022) IF: 2.805
    Role of the long non-coding RNA, SPRR2C, based on an in vitro psoriatic keratinocyte cell model

    DOI: 10.1684/ejd.2022.4247

    PMID: 35866915

    Sample: Ker-Ct Cell,Hacat Cell
  62. BMC Molecular and Cell Biology (2022) IF: 2.813
    Ceramide induces pyroptosis through TXNIP/NLRP3/GSDMD pathway in HUVECs

    DOI: 10.1186/s12860-022-00459-w

    Sample: Human Umbilical Vein Endothelial Cells (Huvecs)
  63. BIOMEDICAL AND ENVIRONMENTAL SCIENCES (2022) IF: 2.831
    Periodontal Ligament Stem Cells Reverse the High Glucose Level-Induced Inflammatory State of Macrophages

    DOI: 10.3967/bes2022.089

    PMID: 35945185

    Sample: Thp-1 Cell
  64. BMC Complementary Medicine and Therapies (2023) IF: 2.838
    Exploration of the mechanism by which Huangqi Guizhi Wuwu decoction inhibits Lps-induced inflammation by regulating macrophage polarization based on network pharmacology

    DOI: 10.1186/s12906-022-03826-4

    Sample: Human Histiocytic Lymphoma (U-937) Cell
  65. Applied Sciences-Basel (2022) IF: 2.838
    Effectiveness of a Cucumber Extract Supplement on Articular Pain in Patients with Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial

    DOI: 10.3390/app13010485

    Sample: Plasma
  66. NEPHRON (2021) IF: 2.847
    XCL1 Aggravates Diabetic Nephropathy-Mediated Renal Glomerular Endothelial Cell Apoptosis and Inflammatory Response via Regulating p53/Nuclear Factor-Kappa B Pathway

    DOI: 10.1159/000518172

    PMID: 34518457

    Sample: Hrgecs
  67. Dermatologic Therapy (2021) IF: 2.851
    Carotid intima-media thickness and serum proinflammatory cytokine levels in rosacea patients without cardiovascular risk factors

    DOI: 10.1111/dth.14733

    PMID: 33389789

    Sample: Serum
  68. MOLECULAR AND CELLULAR BIOCHEMISTRY (2019) IF: 2.884
    Exogenous hydrogen sulfide mitigates LPS + ATP-induced inflammation by inhibiting NLRP3 inflammasome activation and promoting autophagy in L02 cells

    DOI: 10.1007/s11010-019-03519-6

    Sample: Cell Culture Supernatant
  69. INFLAMMATION (2019) IF: 2.939
    Tacrolimus Inhibits TNF-α/IL-17A-Produced pro-Inflammatory Effect on Human Keratinocytes by Regulating IκBζ

    DOI: 10.1007/s10753-019-01151-6

    PMID: 31838663

    Sample: Cell Culture Supernatant
  70. NEUROTOXICITY RESEARCH (2020) IF: 2.992
    The Neuroimmune and Neurotoxic Fingerprint of Major Neurocognitive Psychosis or Deficit Schizophrenia: a Supervised Machine Learning Study

    DOI: 10.1007/s12640-019-00112-z

    Sample: Serum
  71. PLANTA MEDICA (2022) IF: 3.007
    Scutellaria baicalensis Pith-decayed Root Inhibits Macrophage-related Inflammation Through the NF-κB/NLRP3 Pathway to Alleviate LPS-induced Acute Lung Injury

    DOI: 10.1055/a-1878-5704

    Sample: Thp-1 Cell
  72. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    MiR-942-5p alleviates septic acute kidney injury by targeting FOXO3.

    DOI: 10.26355/eurrev_202006_21521

    Sample: Cell Culture Supernatant
  73. JOURNAL OF PERIODONTOLOGY (2017) IF: 3.03
    Salivary Levels of NLRP3 Inflammasome‐Related Proteins as Potential Biomarkers of Periodontal Clinical Status

    DOI: 10.1902/jop.2017.170244

    Sample: Saliva
  74. NEUROCHEMICAL RESEARCH (2020) IF: 3.038
    MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF-κB Signaling Pathway

    DOI: 10.1007/s11064-020-02991-7

    PMID: 32124161

    Sample: Cell Culture Medium
  75. NEUROSCIENCE LETTERS (2022) IF: 3.046
    Role of CD36 rs1761667 AA genotype in the expression of inflammatory cytokines and Parkinson’s disease progression: A case-control study in a northern Han Chinese population

    DOI: 10.1016/j.neulet.2022.136736

    Sample: Plasma
  76. INFLAMMATION RESEARCH (2019) IF: 3.061
    TNF-α/calreticulin dual signaling induced NLRP3 inflammasome activation associated with HuR nucleocytoplasmic shuttling in rheumatoid arthritis

    DOI: 10.1007/s00011-019-01244-w

    Sample: Rheumatoid Arthritis (Ra) Fibroblast-Like Synovioc
  77. INFLAMMATION RESEARCH (2019) IF: 3.061
    Common variants of genes encoding TLR4 and TLR4 pathway members TIRAP and IRAK1 are effective on MCP1, IL6, IL1β, and TNFα levels in type 2 diabetes and insulin resistance

    DOI: 10.1007/s00011-019-01263-7

    Sample: Serum
  78. MOLECULAR IMMUNOLOGY (2019) IF: 3.064
    Ventilator-induced lung injury is alleviated by inhibiting NLRP3 inflammasome activation

    DOI: 10.1016/j.molimm.2019.03.011

    PMID: 30952009

    Sample: Plasma,Cell Culture Supernatant,Bronchoalveolar La
  79. INTERNATIONAL IMMUNOPHARMACOLOGY (2018) IF: 3.118
    S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway

    DOI: 10.1016/j.intimp.2018.11.032

    PMID: 30476824

    Sample: Cell Culture Supernatant
  80. INTERNATIONAL IMMUNOPHARMACOLOGY (2018) IF: 3.118
    Novel anti-inflammatory target of geniposide: Inhibiting Itgβ1/Ras-Erk1/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts

    DOI: 10.1016/j.intimp.2018.09.049

    Sample: Mh7A Cells
  81. JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022) IF: 3.124
    Monocytes subtypes from pleural effusion reveal biomarker candidates for the diagnosis of tuberculosis and malignancy

    DOI: 10.1002/jcla.24579

    PMID: 35819097

    Sample: Pleural Fluid
  82. FISH & SHELLFISH IMMUNOLOGY (2018) IF: 3.185
    Molecular characterization and functional analysis of MyD88 from the tropical sea cucumber, Holothuria leucospilota

    DOI: 10.1016/j.fsi.2018.09.001

    Sample: Hek293T Cells
  83. INFLAMMATION (2020) IF: 3.212
    GPR120 Ameliorates Apoptosis and Inhibits the Production of Inflammatory Cytokines in Renal Tubular Epithelial Cells

    DOI: 10.1007/s10753-020-01346-2

    PMID: 33009637

    Sample: Cell Culture Supernatant
  84. MEDIATORS OF INFLAMMATION (2017) IF: 3.232
    Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study

    DOI: 10.1155/2017/3605350

    Sample: Serum
  85. LIFE SCIENCES (2018) IF: 3.234
    LncRNA PMS2L2 protects ATDC5 chondrocytes against lipopolysaccharide-induced inflammatory injury by sponging miR-203

    DOI: 10.1016/j.lfs.2018.12.020

    PMID: 30550887

    Sample: Cell Culture Supernatant
  86. Bioengineered (2021) IF: 3.269
    N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human bronchial epithelial cells from hypoxia/reoxygenation injury by inactivating p38 MAPK, AKT, ERK1/2, and

    DOI: 10.1080/21655979.2021.1999550

    Sample: Beas-2B Cell
  87. Bioengineered (2021) IF: 3.269
    Knock-down of microRNA miR-556-5p increases cisplatin-sensitivity in non-small cell lung cancer (NSCLC) via activating NLR family pyrin domain containing 3 (NLRP3)-mediated pyroptotic cell death

    DOI: 10.1080/21655979.2021.1971502

    PMID: 34488537

    Sample: A549 Cell,H1299 Cell
  88. Bioengineered (2022) IF: 3.269
    Dihydroartemisinin targets fibroblast growth factor receptor 1 (FGFR1) to inhibit interleukin 17A (IL-17A)-induced hyperproliferation and inflammation of keratinocytes

    DOI: 10.1080/21655979.2021.2021701

    PMID: 35006038

    Sample: Hacat Cell
  89. Bioengineered (2022) IF: 3.269
    Circ_0001897 regulates high glucose-induced angiogenesis and inflammation in retinal microvascular endothelial cells through miR-29c-3p/transforming growth factor beta 2 axis

    DOI: 10.1080/21655979.2022.2070997

    PMID: 35510503

    Sample: Human Retinal Microvascular Endothelial Cell (Hrec
  90. Bioengineered (2021) IF: 3.269
    Carvedilol activates nuclear factor E2-related factor 2/ antioxidant response element pathway to inhibit oxidative stress and apoptosis of retinal pigment epithelial cells induced by high glucose

    DOI: 10.1080/21655979.2021.2012627

    PMID: 34898371

    Sample: Arpe-19 Cell
  91. CELLULAR IMMUNOLOGY (2019) IF: 3.291
    DosR antigen Rv1737c induces activation of macrophages dependent on the TLR2 pathway

    DOI: 10.1016/j.cellimm.2019.103947

    Sample: Thp-1 Cells
  92. FISH & SHELLFISH IMMUNOLOGY (2019) IF: 3.298
    The first cloned echinoderm tumor necrosis factor receptor from Holothuria leucospilota: Molecular characterization and functional analysis

    DOI: 10.1016/j.fsi.2019.08.008

    PMID: 31394160

    Sample: Cell Culture Supernatant
  93. Clinical & Translational Oncology (2022) IF: 3.34
    Cancer cell-derived exosomal LINC00313 induces M2 macrophage differentiation in non-small cell lung cancer

    DOI: 10.1007/s12094-022-02907-7

    PMID: 35980503

    Sample: Thp-1 Cell,H1299 Cell
  94. EXPERIMENTAL CELL RESEARCH (2020) IF: 3.383
    iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin–angiotensin system-mediated congenital ureteropelvic junction obstruction

    DOI: 10.1016/j.yexcr.2020.112086

    Sample: Serum,Cell Sample
  95. MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2021) IF: 3.402
    Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced injury in human tubule epithelial cells by regulating miR-93-5p/TXNIP axis

    DOI: 10.1007/s00430-021-00705-6

    PMID: 33885954

    Sample: Cell Culture Supernatant
  96. Journal of Medical Biochemistry (2022) IF: 3.402
    Cul4a attenuates LPS-induced acute kidney injury via blocking NF-kB signaling pathway in sepsis

    DOI: 10.5937/jomb0-33096

    Sample: Hk-2 Cell
  97. Biomed Research International (2020) IF: 3.411
    CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis

    DOI: 10.1155/2020/5341247

    Sample: Serum
  98. JOURNAL OF ETHNOPHARMACOLOGY (2019) IF: 3.414
    Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-κB signaling pathway

    DOI: 10.1016/j.jep.2019.112361

    PMID: 31683033

    Sample: Cell Culture Supernatant
  99. JOURNAL OF ETHNOPHARMACOLOGY (2019) IF: 3.414
    Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology

    DOI: 10.1016/j.jep.2019.112433

    PMID: 31783135

    Sample: Cell Culture Supernatant
  100. Frontiers in Pediatrics (2022) IF: 3.418
    Hyperoxia Induced Bronchopulmonary Dysplasia-Like Inflammation via miR34a-TNIP2-IL-1β Pathway

    DOI: 10.3389/fped.2022.805860

    Sample: Sputum
  101. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020) IF: 3.437
    Role of aldosterone in the activation of primary mice hepatic stellate cell and liver fibrosis via NLRP3 inflammasome

    DOI: 10.1111/jgh.14961

    PMID: 31860730

    Sample: Serum,Tissue Homogenate
  102. JOURNAL OF CELLULAR BIOCHEMISTRY (2019) IF: 3.448
    Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast‐like synoviocytes through AKT/FOXO1 signaling

    DOI: 10.1002/jcb.28724

    Sample: Rheumatoid Arthritis (Ra) Fibroblast-Like Synovioc
  103. EXPERIMENTAL EYE RESEARCH (2021) IF: 3.467
    Wedelolactone ameliorates Pseudomonas aeruginosa-induced inflammation and corneal injury by suppressing caspase-4/5/11/GSDMD-mediated non-canonical pyroptosis

    DOI: 10.1016/j.exer.2021.108750

    PMID: 34481822

    Sample: Pihcks
  104. JOURNAL OF NEUROIMMUNOLOGY (2022) IF: 3.478
    Association between pro-inflammatory cytokines in cerebrospinal fluid and headache in patients with aneurysmal subarachnoid hemorrhage

    DOI: 10.1016/j.jneuroim.2022.577841

    PMID: 35279426

    Sample: Cerebrospinal Fluid (Csf)
  105. MEDIATORS OF INFLAMMATION (2018) IF: 3.549
    Increased Expression of TLR10 in B Cell Subsets Correlates with Disease Activity in Rheumatoid Arthritis

    DOI: 10.1155/2018/9372436

    Sample: Serum
  106. Nanoscale Research Letters (2020) IF: 3.578
    Nec-1 Attenuates Neurotoxicity Induced by Titanium Dioxide Nanomaterials on Sh-Sy5y Cells Through RIP1

    DOI: 10.1186/s11671-020-03300-5

    Sample: Sh-Sy5Y Cell
  107. Clinical Oral Investigations (2022) IF: 3.606
    Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis

    DOI: 10.1007/s00784-022-04681-w

    PMID: 35986791

    Sample: Gingival Crevicular Fluid (Gcf)
  108. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021) IF: 3.652
    Proanthocyanidins attenuate the high glucose-induced damage of retinal pigment epithelial cells by attenuating oxidative stress and inhibiting activation of the NLRP3 inflammasome

    DOI: 10.1002/jbt.22845

    PMID: 34338401

    Sample: Arpe-19 Cell
  109. BMC Complementary and Alternative Medicine (2021) IF: 3.659
    Myrtenal and β-caryophyllene oxide screened from Liquidambaris Fructus suppress NLRP3 inflammasome components in rheumatoid arthritis

    DOI: 10.1186/s12906-021-03410-2

    PMID: 34583676

    Sample: Serum,Ra-Fls
  110. APOPTOSIS (2015) IF: 3.685
    strain FP10

    DOI: 10.1007/s10495-015-1162-9

    Sample: Cell Culture Supernatant
  111. JOURNAL OF ETHNOPHARMACOLOGY (2020) IF: 3.69
    Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways

    DOI: 10.1016/j.jep.2020.113039

    PMID: 32497675

    Sample: Serum,Cell Culture Supernatant
  112. BIOMEDICINE & PHARMACOTHERAPY (2019) IF: 3.743
    Sapylin (OK-432) alters inflammation and angiogenesis in vivo and vitro

    DOI: 10.1016/j.biopha.2019.108706

    PMID: 30844656

    Sample: Wound Drainage Fluid
  113. INFLAMMOPHARMACOLOGY (2019) IF: 3.838
    Tocilizumab attenuates acute lung and kidney injuries and improves survival in a rat model of sepsis via down-regulation of NF-κB/JNK: a possible role of P-glycoprotein

    DOI: 10.1007/s10787-019-00628-y

    PMID: 31440860

    Sample: Serum
  114. BIOSCIENCE REPORTS (2019) IF: 3.84
    Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production

    DOI: 10.1042/BSR20191252

    PMID: 31651935

    Sample: Serum,Plasma,Cell Sample
  115. JOURNAL OF AFFECTIVE DISORDERS (2020) IF: 3.892
    Construction of an exposure-pathway-phenotype in children with depression due to transfusion-dependent thalassemia: Results of (un)supervised machine learning.

    DOI: 10.1016/j.jad.2020.12.089

    Sample: Serum
  116. Annals of Translational Medicine (2021) IF: 3.932
    Effect and mechanism of phospholipid scramblase 4 (PLSCR4) on lipopolysaccharide (LPS)-induced injury to human pulmonary microvascular endothelial cells

    DOI: 10.21037/atm-20-7983

    PMID: 33569461

    Sample: Hpmecs
  117. Annals of Translational Medicine (2022) IF: 3.932
    Advanced platelet-rich fibrin promotes the paracrine function and proliferation of adipose-derived stem cells and contributes to micro-autologous fat transplantation by modulating HIF-1α and VEGF

    DOI: 10.21037/atm-21-6812

    Sample: Adipose-Derived Stem Cell (Ascs)
  118. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    Mammalian Ste20-like kinase 4 inhibits the inflammatory response in Aspergillus fumigatus keratitis

    DOI: 10.1016/j.intimp.2020.107021

    PMID: 33182037

    Sample: Cell Lysate
  119. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    Inhibition of HMGB1 involved in the protective of salidroside on liver injury in diabetes mice

    DOI: 10.1016/j.intimp.2020.106987

    PMID: 33217691

    Sample: Cell Culture Supernatant
  120. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    IL-38 alleviates the inflammatory response and the degeneration of nucleus pulposus cells via inhibition of the NF-κB signaling pathway in vitro

    DOI: 10.1016/j.intimp.2020.106592

    PMID: 32502922

    Sample: Cell Culture Supernatant
  121. JOURNAL OF PERIODONTAL RESEARCH (2022) IF: 3.946
    Asymmetric and symmetric dimethylarginine gingival crevicular fluid levels in periodontitis

    DOI: 10.1111/jre.13087

    Sample: Gingival Crevicular Fluid(Gcf)
  122. NEUROCHEMICAL RESEARCH (2021) IF: 3.996
    Silencing of UCA1 Protects Against MPP+-Induced Cytotoxicity in SK-N-SH Cells via Modulating KCTD20 Expression by Sponging miR-423-5p

    DOI: 10.1007/s11064-020-03214-9

    Sample: Cell Culture Supernatant
  123. Scientific Reports (2020) IF: 3.998
    Validation of Salivary Markers, IL-1β, IL-8 and Lgals3bp for Detection of Oral Squamous Cell Carcinoma in an Indian Population

    DOI: 10.1038/s41598-020-64494-3

    Sample: Saliva
  124. Scientific Reports (2020) IF: 3.998
    Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits

    DOI: 10.1038/s41598-020-68543-9

    PMID: 32669704

    Sample: Cell Culture Supernatant
  125. Pediatric Obesity (2021) IF: 4
    The effects of Mediterranean diet on hepatic steatosis, oxidative stress, and inflammation in adolescents with non-alcoholic fatty liver disease: A randomized controlled trial

    DOI: 10.1111/ijpo.12872

    PMID: 34881510

    Sample: Serum
  126. American Journal of Translational Research (2021) IF: 4.06
    Effect of levetiracetam in combination with topiramate on immune function, cognitive function, and neuronal nutritional status of children with intractable epilepsy

    PMID: 34650715

    Sample: Serum
  127. INFLAMMATION (2022) IF: 4.092
    LncRNA FLG-AS1 Mitigates Diabetic Retinopathy by Regulating Retinal Epithelial Cell Inflammation, Oxidative Stress, and Apoptosis via miR-380-3p/SOCS6 Axis

    DOI: 10.1007/s10753-022-01665-6

    PMID: 35461393

    Sample: Arpe-19 Cell
  128. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    LncRNA MEG3 ameliorates NiO nanoparticles-induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway

    DOI: 10.1002/tox.23464

    PMID: 35006638

    Sample: A549 Cell
  129. Drug Design Development and Therapy (2021) IF: 4.162
    Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling

    DOI: 10.2147/DDDT.S325814

    PMID: 34764638

    Sample: Nthy-Ori 3–1 Cells
  130. Frontiers in Pharmacology (2020) IF: 4.225
    Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Atractylodes macrocephala Koidz. for the Treatment of Chronic Gastritis

    DOI: 10.3389/fphar.2019.01629

    PMID: 32063848

    Sample: Cell Culture Supernatant
  131. SAUDI PHARMACEUTICAL JOURNAL (2021) IF: 4.33
    Impact of Docosahexaenoic acid supplementation on proinflammatory cytokines release and the development of Necrotizing enterocolitis in preterm Neonates: A randomized controlled study

    DOI: 10.1016/j.jsps.2021.09.012

    PMID: 34819793

    Sample: Blood
  132. Epigenomics (2023) IF: 4.357
    Low-dose 5-aza-2′-deoxycytidine protects against early renal injury by increasing klotho expression

    DOI: 10.2217/epi-2022-0430

    Sample: Serum,Hk-2 Cell
  133. PLoS Neglected Tropical Diseases (2021) IF: 4.411
    Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion

    DOI: 10.1371/journal.pntd.0009508

    PMID: 34237073

    Sample: Pleural Fluid
  134. EUROPEAN JOURNAL OF PHARMACOLOGY (2019) IF: 4.432
    Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs

    DOI: 10.1016/j.ejphar.2019.172797

    Sample: Huvecs Cells
  135. CELL BIOLOGY INTERNATIONAL (2023) IF: 4.473
    TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation

    DOI: 10.1002/cbin.12002

    Sample: Human Retinal Capillary Endothelial Cells (Hrcecs)
  136. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545
    Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis

    DOI: 10.1016/j.biopha.2020.110326

    Sample: Cell Culture Supernatant
  137. BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545
    LncRNA SNHG5 regulates cell apoptosis and inflammation by miR-132/PTEN axis in COPD

    DOI: 10.1016/j.biopha.2020.110016

    PMID: 32145584

    Sample: Cell Culture Supernatant
  138. INFLAMMATION RESEARCH (2021) IF: 4.575
    S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1

    DOI: 10.1007/s00011-021-01489-4

    PMID: 34459932

    Sample: Hrec
  139. FISH & SHELLFISH IMMUNOLOGY (2020) IF: 4.581
    Molecular characterization, inducible expression and functional analysis of an IKKβ from the tropical sea cucumber Holothuria leucospilota

    DOI: 10.1016/j.fsi.2020.06.024

    PMID: 32585358

    Sample: Cell Culture Supernatant
  140. Oxidative Medicine and Cellular Longevity (2017) IF: 4.593
    ROS-Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A-Sonodynamic Therapy in THP-1 Macrophages

    DOI: 10.1155/2017/8519169

    Sample: Cell Culture Supernatant
  141. INTERNATIONAL JOURNAL OF CARDIOLOGY (2016) IF: 4.638
    Melatonin effects on myocardial ischemia–reperfusion injury: Impact on the outcome in patients undergoing coronary artery bypass grafting surgery

    DOI: 10.1016/j.ijcard.2016.07.108

    Sample: Plasma
  142. JOURNAL OF PSYCHIATRIC RESEARCH (2022) IF: 4.791
    Comparison of cognitive impairments with lipid profiles and inflammatory biomarkers in unipolar and bipolar depression

    DOI: 10.1016/j.jpsychires.2022.04.002

    PMID: 35429740

    Sample: Serum
  143. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021) IF: 4.799
    The Role of SREC-Ⅰ in Innate Immunity to Aspergillus fumigatus Keratitis

    DOI: 10.1167/iovs.62.9.12

    PMID: 34236384

    Sample: Hcecs Cells
  144. Journal of Immunology Research (2021) IF: 4.818
    Remote Inflammatory Preconditioning Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Intrinsic Apoptosis in Rats

    DOI: 10.1155/2021/1125199

    PMID: 34595242

    Sample: Serum
  145. Journal of Immunology Research (2021) IF: 4.818
    Moesin Is a Novel Biomarker of Endothelial Injury in Sepsis

    DOI: 10.1155/2021/6695679

    PMID: 33628853

    Sample: Cell Culture Supernatant(Hmecs)
  146. Aging-US (2020) IF: 4.831
    In situ self-assembly of Au-antimiR-155 nanocomplexes mediates TLR3-dependent apoptosis in hepatocellular carcinoma cells.

    DOI: 10.18632/aging.103799

    Sample: Cell Culture Medium
  147. MOLECULES (2022) IF: 4.927
    Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide

    DOI: 10.3390/molecules27134264

    PMID: 35807509

    Sample: Human Fibroblast Cell
  148. INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
    Isoliquiritigenin alleviates P. gingivalis-LPS/ATP-induced pyroptosis by inhibiting NF-κB/ NLRP3/GSDMD signals in human gingival fibroblasts

    DOI: 10.1016/j.intimp.2021.108338

    PMID: 34794890

    Sample: Hgfs Cells
  149. INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
    Hypoxia and Porphyromonas gingivalis-lipopolysaccharide synergistically induce NLRP3 inflammasome activation in human gingival fibroblasts

    DOI: 10.1016/j.intimp.2021.107456

    PMID: 33588175

    Sample: Cell Culture Supernatant
  150. INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 4.932
    Chlorogenic acid attenuates inflammation in LPS-induced Human gingival fibroblasts via CysLT1R/Nrf2/NLRP3 signaling

    DOI: 10.1016/j.intimp.2022.108706

    PMID: 35313270

    Sample: Human Gingival Fibroblasts (Hgfs)
  151. JOURNAL OF LEUKOCYTE BIOLOGY (2022) IF: 4.962
    Periodontal ligament stem cells promote polarization of M2 macrophages

    DOI: 10.1002/JLB.1MA1220-853RR

    PMID: 34982483

    Sample: Thp-1 Cell
  152. PPAR Research (2019) IF: 4.964
    Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR- Functional Module of Autophagy in Rheumatoid Arthritis

    DOI: 10.1155/2019/6403504

    Sample: Rheumatoid Arthritis (Ra) Fibroblast-Like Synovioc
  153. Advanced Therapeutics (2022) IF: 5.003
    Fructose-coated Ångstrom silver particles suppress gastric cancer growth by activating gasdermin D-mediated pyroptosis

    DOI: 10.1002/adtp.202200100

    Sample: Bgc-823 Cell,Sgc-7901 Cells
  154. LIFE SCIENCES (2022) IF: 5.037
    STING up-regulates VEGF expression in oxidative stress-induced senescence of retinal pigment epithelium via NF-κB/HIF-1α pathway

    DOI: 10.1016/j.lfs.2021.120089

    PMID: 35007563

    Sample: Arpe-19 Cell
  155. CELL PROLIFERATION (2019) IF: 5.039
    Inhibition of CREB‐mediated ZO‐1 and activation of NF‐κB‐induced IL‐6 by colonic epithelial MCT4 destroys intestinal barrier function

    DOI: 10.1111/cpr.12673

    Sample: Caco2 Cells,Ht‐29 Cell
  156. Journal of Functional Foods (2022) IF: 5.223
    High fiber multigrain supplementation improved disease activity score, circulating inflammatory and oxidative stress biomarkers in rheumatoid arthritis (RA) patients: A randomized human clinical trial

    DOI: 10.1016/j.jff.2022.105392

    Sample: Blood
  157. Frontiers in Cellular and Infection Microbiology (2021) IF: 5.293
    GLUT3 as an Intersection of Glycerophospholipid Metabolism and the Innate Immune Response to Candida albicans

    DOI: 10.3389/fcimb.2021.648988

    Sample: Thp-1 Cells
  158. Food & Function (2022) IF: 5.396
    A randomised, double-blind, placebo-controlled trial of Bifidobacterium bifidum CCFM16 for manipulation of gut microbiota and relief from chronic constipation

    DOI: 10.1039/D1FO03896F

    Sample: Serum
  159. BRITISH JOURNAL OF PHARMACOLOGY (2017) IF: 5.491
    The TIR/BB‐loop mimetic AS‐1 prevents non‐alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3‐ASC inflammasome activation

    DOI: 10.1111/bph.13786

    Sample: Cell Culture Supernatant
  160. Molecular Therapy-Nucleic Acids (2018) IF: 5.66
    miR-93-5p-Containing Exosomes Treatment Attenuates Acute Myocardial Infarction-Induced Myocardial Damage

    DOI: 10.1016/j.omtn.2018.01.010

    Sample: Serum
  161. Aging-US (2022) IF: 5.682
    The TLR4/NF-κB/MAGI-2 signaling pathway mediates postoperative delirium

    DOI: 10.18632/aging.203955

    Sample: Plasma,Cerebrospinal Fluid
  162. MOLECULAR NEUROBIOLOGY (2022) IF: 5.682
    Acrylamide Induces Neurotoxicity in SH-SY5Y Cells via NLRP3-mediated Pyroptosis

    DOI: 10.1007/s12035-022-03098-6

  163. Cell Communication and Signaling (2022) IF: 5.712
    The ROCK-ezrin signaling pathway mediates LPS-induced cytokine production in pulmonary alveolar epithelial cells

    DOI: 10.1186/s12964-022-00879-3

    PMID: 35551614

    Sample: A549 Cell
  164. INTERNATIONAL IMMUNOPHARMACOLOGY (2023) IF: 5.714
    Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats

    DOI: 10.1016/j.intimp.2022.109659

    Sample: Caco-2 Cell
  165. INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 5.714
    CircVAPA contributes to hyper-proliferation and inflammation of keratinocytes through miR-125b-5p/sirt6 axis in psoriasis

    DOI: 10.1016/j.intimp.2022.109632

    Sample: Hacat Cells
  166. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208
    Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo

    DOI: 10.3390/ijms232416134

    Sample: Thp-1 Cells
  167. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021) IF: 6.291
    Novel insights into the role of BRD4 in fine particulate matter induced airway hyperresponsiveness

    DOI: 10.1016/j.ecoenv.2021.112440

    PMID: 34175826

    Sample: Hasmcs Cells
  168. PHYTOTHERAPY RESEARCH (2022) IF: 6.388
    Atractylodin targets GLA to regulate D-mannose metabolism to inhibit osteogenic differentiation of human valve interstitial cells and ameliorate aortic valve calcification

    DOI: 10.1002/ptr.7628

    PMID: 36199227

    Sample: Hvics
  169. ENVIRONMENTAL RESEARCH (2021) IF: 6.498
    Changes in genotoxicity, inflammatory and oxidative stress parameters of workers in marble processing plants

    DOI: 10.1016/j.envres.2021.111209

    PMID: 33895109

    Sample: Plasma
  170. Pharmaceutics (2022) IF: 6.525
    In Vitro Antibacterial and Anti-Inflammatory Activity of Arctostaphylos uva-ursi Leaf Extract against Cutibacterium acnes

    DOI: 10.3390/pharmaceutics14091952

    PMID: 36145700

    Sample: Hacat Cell
  171. Oxidative Medicine and Cellular Longevity (2022) IF: 6.543
    Silencing ATF3 Might Delay TBHP-Induced Intervertebral Disc Degeneration by Repressing NPC Ferroptosis, Apoptosis, and ECM Degradation

    DOI: 10.1155/2022/4235126

    PMID: 35480873

    Sample: Npcs
  172. Oxidative Medicine and Cellular Longevity (2022) IF: 6.543
    DNA Methyltransferase 3b Accelerates the Process of Atherosclerosis

    DOI: 10.1155/2022/5249367

    PMID: 35422896

    Sample: Tregs
  173. Oxidative Medicine and Cellular Longevity (2022) IF: 6.543
    Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration

    DOI: 10.1155/2022/2776440

    PMID: 35039758

    Sample: Nucleus Pulposus Cell (Npcs)
  174. Oxidative Medicine and Cellular Longevity (2021) IF: 6.543
    Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo

    DOI: 10.1155/2021/5584447

    PMID: 34239691

    Sample: Np Cells
  175. Cancers (2023) IF: 6.575
    Salivary Interleukin Levels in Oral Squamous Cell Carcinoma and Oral Epithelial Dysplasia: Findings from a Sri Lankan Study

    DOI: 10.3390/cancers15051510

    Sample: Saliva
  176. Frontiers in Cell and Developmental Biology (2021) IF: 6.684
    Fexofenadine Protects Against Intervertebral Disc Degeneration Through TNF Signaling

    DOI: 10.3389/fcell.2021.687024

    Sample: Np Cell
  177. Frontiers in Cell and Developmental Biology (2021) IF: 6.684
    Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration

    DOI: 10.3389/fcell.2021.672847

    PMID: 34239872

    Sample: Np Cells
  178. Nutrients (2022) IF: 6.706
    CCN1/Integrin α5β1 Instigates Free Fatty Acid-Induced Hepatocyte Lipid Accumulation and Pyroptosis through NLRP3 Inflammasome Activation

    DOI: 10.3390/nu14183871

    Sample: Lo2 Hepatocytes
  179. Nutrients (2022) IF: 6.706
    Alteration in Gut Microbiota Associated with Zinc Deficiency in School-Age Children

    DOI: 10.3390/nu14142895

    PMID: 35889856

    Sample: Serum
  180. Journal of Inflammation Research (2021) IF: 6.922
    Silenced SNHG1 Inhibited Epithelial-Mesenchymal Transition and Inflammatory Response of ARPE-19 Cells Induced by High Glucose

    DOI: 10.2147/JIR.S299010

    Sample: Arpe-19 Cell
  181. Journal of Inflammation Research (2022) IF: 6.922
    Long Noncoding RNA MIAT Regulates Hyperosmotic Stress-Induced Corneal Epithelial Cell Injury via Inhibiting the Caspase-1-Dependent Pyroptosis and Apoptosis in Dry Eye Disease

    DOI: 10.2147/JIR.S361541

    PMID: 35676970

    Sample: Human Corneal Epithelial Cell (Hcecs)
  182. Journal of Inflammation Research (2021) IF: 6.922
    Anti-Inflammatory Effects of Four Psilocybin-Containing Magic Mushroom Water Extracts in vitro on 15-Lipoxygenase Activity and on Lipopolysaccharide-Induced Cyclooxygenase-2 and Inflammatory Cytokines in Human U937 Macrophage Cells

    DOI: 10.2147/JIR.S317182

    Sample: U937 Cell
  183. JOURNAL OF PERIODONTOLOGY (2021) IF: 6.993
    Periodontitis activates the NLRP3 inflammasome in serum and saliva

    DOI: 10.1002/JPER.21-0049

    PMID: 34008185

    Sample: Serum
  184. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022) IF: 7.129
    Autophagy promotes GSDME-mediated pyroptosis via intrinsic and extrinsic apoptotic pathways in cobalt chloride-induced hypoxia reoxygenation-acute kidney injury

    DOI: 10.1016/j.ecoenv.2022.113881

    PMID: 35863214

    Sample: Hk-2 Cell
  185. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2023) IF: 7.129
    Acute liver injury induced by carbon tetrachloride reversal by Gandankang aqueous extracts through nuclear factor erythroid 2-related factor 2 signaling pathway

    DOI: 10.1016/j.ecoenv.2023.114527

    Sample: Hepg2 Cell
  186. JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020) IF: 7.143
    MicroRNA-101-3p Downregulates TLR2 Expression, Leading to Reduction in Cytokine Production by Treponema pallidum–Stimulated Macrophages

    DOI: 10.1016/j.jid.2019.12.012

    Sample: Plasma,Thp-1 Cell
  187. CARBOHYDRATE POLYMERS (2020) IF: 7.182
    The effect of doxycycline-containing chitosan/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease

    DOI: 10.1016/j.carbpol.2020.116163

    PMID: 32241426

    Sample: Gingival Crevicular Fluid
  188. BRAIN BEHAVIOR AND IMMUNITY (2021) IF: 7.217
    Bifidobacterium breve CCFM1025 attenuates major depression disorder via regulating gut microbiome and tryptophan metabolism: A randomized clinical trial

    DOI: 10.1016/j.bbi.2021.11.023

    PMID: 34875345

    Sample: Serum
  189. Oxidative Medicine and Cellular Longevity (2022) IF: 7.31
    Change in Oxidative Stress and Mitochondrial Dynamics in Response to Elevated Cold-Inducible RNA-Binding Protein in Cardiac Surgery-Associated Acute Kidney Injury

    DOI: 10.1155/2022/3576892

    PMID: 35855864

    Sample: Serum
  190. FOOD RESEARCH INTERNATIONAL (2022) IF: 7.425
    N-3 polyunsaturated fatty acids protect esophageal epithelial cells from acid exposure

    DOI: 10.1016/j.foodres.2022.111943

    PMID: 36461199

    Sample: Het-1A Cell
  191. Frontiers in Immunology (2022) IF: 7.561
    TIPE2 May Target the Nrf2/HO-1 Pathway to Inhibit M1 Macrophage-Related Neutrophilic Inflammation in Asthma.

    DOI: 10.3389/fimmu.2022.883885

    Sample: Thp-1 Monocytes
  192. Cells (2022) IF: 7.666
    Hypoxia-Induced HIF-1α Expression Promotes Neurogenic Bladder Fibrosis via EMT and Pyroptosis

    DOI: 10.3390/cells11233836

  193. Cell Reports (2020) IF: 8.109
    Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis

    DOI: 10.1016/j.celrep.2020.107990

    PMID: 32755583

    Sample: Plasma
  194. Cell Death & Disease (2021) IF: 8.469
    Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site

    DOI: 10.1038/s41419-020-03317-9

    PMID: 33431796

    Sample: Serum,Cell Culture Supernatant
  195. CANCER LETTERS (2022) IF: 8.679
    Decreased CXCR2 expression on circulating monocytes of colorectal cancer impairs recruitment and induces Re-education of tumor-associated macrophages

    DOI: 10.1016/j.canlet.2022.01.004

    PMID: 34999169

    Sample: Serum,Thp-1 Cell,Human Circulating Cd14+ Monocytes
  196. EXPERIMENTAL AND MOLECULAR MEDICINE (2019) IF: 8.718
    Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc

    DOI: 10.1038/s12276-019-0310-7

    Sample: Np Cells
  197. EXPERIMENTAL AND MOLECULAR MEDICINE (2022) IF: 8.718
    Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

    DOI: 10.1038/s12276-022-00729-9

    PMID: 35145201

    Sample: Nucleus Pulposus (Np) Cell
  198. Frontiers in Immunology (2022) IF: 8.786
    METTL3 inhibits inflammation of retinal pigment epithelium cells by regulating NR2F1 in an m6A-dependent manner

    DOI: 10.3389/fimmu.2022.905211

    PMID: 35936005

    Sample: Rpe Cell
  199. Molecular Therapy-Nucleic Acids (2021) IF: 8.886
    Enhancer RNA lnc-CES1-1 inhibits decidual cell migration by interacting with RNA-binding protein FUS and activating PPARγ in URPL

    DOI: 10.1016/j.omtn.2021.02.018

    PMID: 33738142

    Sample: Cell Culture Supernatant(Htr-8/Svneo Cells,Jeg-3 C
  200. Journal of Neuroinflammation (2022) IF: 9.587
    Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro

    DOI: 10.1186/s12974-022-02535-6

    PMID: 35768823

    Sample: Cerebrospinal Fluid (Csf),Peripheral Monocytes
  201. ENVIRONMENTAL POLLUTION (2022) IF: 9.988
    Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line

    DOI: 10.1016/j.envpol.2022.120217

    PMID: 36155221

    Sample: Hmc3 Cell
  202. JOURNAL OF NANOBIOTECHNOLOGY (2022) IF: 10.435
    Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis

    DOI: 10.1186/s12951-022-01288-x

    PMID: 35248068

    Sample: Serum
  203. JOURNAL OF PINEAL RESEARCH (2023) IF: 12.081
    Melatonin inhibits atherosclerosis progression via Galectin-3 downregulation to enhance autophagy and inhibit inflammation

    DOI: 10.1111/jpi.12855

    Sample: Serum
  204. MOLECULAR PSYCHIATRY (2020) IF: 12.384
    LncRNA- AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia

    DOI: 10.1038/s41380-020-0662-3

    Sample: Serum
  205. HEPATOLOGY (2020) IF: 17.425
    Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD

    DOI: 10.1002/hep.31056

    PMID: 31808577

    Sample: Serum
  206. CELL (2020) IF: 38.637
    Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

    DOI: 10.1016/j.cell.2020.08.009

    PMID: 33015716

    Sample: Cell Culture Medium
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